The Will Wang Lab
at Sanford Burnham Prebys Medical Discovery Institute
Research
Our goal is to understand how every cell in the body works together to maintain function and health.
The Wang lab focuses on neuromuscular disorders with an emphasis on the normal role of immune cells in supporting efficient regenerative processes and how these mechanics go awry in autoimmune diseases and aging.
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We use state-of-the-art spatial omics and neural network analysis to probe cellular interactions at single cell resolution.
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We are making discoveries in multicellular mechanisms that transform our understanding of:
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How stem cells carry out the process of healing
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The degenerative tissue microenvironment that lead to chronic disease
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Cellular and molecular basis of biological aging
Our Interdisciplinary Approach
Detecting 60+ proteins in a single tissue
News & Events
Select Publications
Wang, Y. X., Palla, A. R., Ho, A. T. V., Robinson, D. C. L., Ravichandran, M., Markov, G. J., Mai, T., Still, C., Balsubramani, A., Nair, S., Holbrook, C. A., Yang, A. V., Kraft, P. E., Su, S., Burns, D. M., Yucel, N. D., Qi, L. S., Kundaje, A., & Blau, H. M. (2025). Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. Cell Stem Cell, S1934-5909(25)00192-4. https://doi.org/10.1016/j.stem.2025.05.012
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